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Thus, a vaccine approach Funny 11 Years 2010 2021 One Direction Thank You For The Memories Signature Shirts that can generate neoantigen-specific cell-mediated immune responses may be more effective. Third, patients were not selected for rindopepimut vaccine by MHC haplotype. Although predictions of neoantigen binding to HLA molecules are imperfect, the consideration of target affinity may increase the likelihood of effective T cell priming and target recognition in patients following vaccine treatment. It is likely that combination immunotherapies will be necessary to increase therapeutic efficacy. Specifically, many personalized neoantigen vaccine approaches are combining tailored vaccines with immune modulating agents, such as checkpoint blockade therapy.
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